Virosart<sup>®</sup> Media  |產品專區<br/>Products & Services  |生物製程解決方案<br/>Bioprocess Solutions    |過濾 | 純化應用<br/>Filtration | Purification   |病毒過濾∣移除<br/>Virus Filtration

Virosart® Media


First virus retentive filter for cell culture media. Virus-retentive filtration is a highly efficient method for viral risk mitigation of cell culture media. This filter targets both non-enveloped viruses and large enveloped viruses, MLV etc.




Virosart® Media


First virus retentive filter for cell culture media

Virus-retentive filtration is a highly efficient method for viral risk mitigation of cell culture media. This filter targets both non-enveloped viruses, such as MVM and vesivirus, and large enveloped viruses, such as MLV. Virosart® Media is especially designed for virus filtration of chemically defined cell culture media.

 

Virus risk mitigation in media preparation

Multiple bioreactor contaminations reported over the past several years have been caused by small, non-enveloped viruses like MVM and vesivirus derived from raw materials.


New strategy

A new strategy is the removal of viruses before the bioreactor already after media preparation to prevent potential contaminations of the bioreactor. Virus Filtration is a proven and well established technology within the market to remove all kind of viruses (> 20 nm range).


Our solution: Virosart® Media

Virosart® Media is a virus retentive filter specially developed for upstream applications. The newly developed media filter overcomes today’s bottlenecks of virus filters originally developed for downstream applications and provides a cost effective solution in upstream with highest filter capacity for cell culture media.

Highest safety for the bioreactor

  • 4 LRV for small non-enveloped viruses
  • Mycoplasma orale: sterile (≥7)
  • Leptospira licerasiae: sterile (≥7)
  • Sterilizing grade filter based on HIMA/ASTM F838

New high-performance PES membranes

  • Perfect economical solution for upstream virus media filtration
  • Highest capacities and flow rates
  • No impact on cell fulture performance

Sterile delivery due to gamma irradiatable capsule design

  • Ready to use
  • Easy implementation into single-use processes

Applications

Viral risk mitigation in media preparation of:

  • Chemically defined cell culture media
  • Addition of media supplement such as CaCl2
  • Powder as well as liquid media
  • Sterile media
 

Technical proof

The performance of the newly developed virus retentive filter for risk mitigation within cell culture media was evaluated for different commercially available media.

Retentive capacities

The Virosart® Media shows high retention for all tested organisms. It especially shows high rentention of ≥ 107 CFU/cm² for Acheloplasma laidlawii, Leptospira licerasiae and Brevundimonas diminuta.

Performance

In total >25 different commercially available cell culture media were tested with the Virosart® Media.

Organism Description LRV
PP7 Proven bacteriophage model for parvoviruses 4.9
Leptospira licerasiae Bacteria type not retainable by 0.1 μm membranes > 7
Acheoplasma laidlawii Standard model mycoplasma > 7
Mycoplasma orale Worst case model mycoplasma > 7
Brevundimonas diminuta Standard model based on ASTM guideline for sterilizing grade filters > 7

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Virosart® Media

First virus retentive filter for cell culture media. Virus-retentive filtration is a highly efficient method for viral risk mitigation of cell culture media. This filter targets both non-enveloped viruses and large enveloped viruses, MLV etc.