Flexel® drum bags for LevMixer® are specially adapted to fit in cylindrical tanks. They contain an off-center levitated impeller that generates gentle mixing forces, and are ideal for ultraclean mixing, low-shear mixing, liquid-liquid mixing, rehomogenization and resuspension. The drum bags can be ordered in a choice of 50 L to 1,000 L
Shear sensitive proteins can degrade during mixing conditions. This can affect product quality and generate aggregates that in turn yield premature fouling of sterilizing filters.
By combining low shear mixing attributes and high torque, Flexel® for LevMixer® is ideal for the homogenization, viral inactivation and formulation of sensitive drug substances and drug products. The levitated impeller eliminates shear effects that can impact your product quality and avoid the generation of aggregates and particles that can reduce your filtration performance.
For Buffer & Media applications, we recommend you to use the Powerful Flexel® for Magnetic.
Because media powders tend to float, a strong vortex is required for their downward entrainment to the impeller and subsequent dissolution.
The strong vertical vortex of Flexel® for Magnetic Mixer combined with the baffle effect of the cubical design allows instant downward movement and efficient dissolution of floating powders. The high torque provides a fast dissolution of media powders or diatomaceous earth powders used with Sartoclear® Dynamics and an efficient mixing of high concentration buffers or viscous products.
For Downstream intermediates purifcation, drug substances and drug products formulation, we recommend you to use the Low Shear Flexel® for LevMixer®.
The powder transfer bag system is designed for powder-delivery applications where high containment and product recovery are required, such as preparation of media and buffers and product formulation. The system is a single-use alternative to conventional reusable rigid containers and plastic pouches. Available in volumes of 15 l to 30 l, the powder transfer bag system is routinely used in all scale-up levels from process development to commercial biomanufacturing.