Sartoclear Dynamics<sup>®</sup>  |產品專區<br/>Products & Services  |生物製程解決方案<br/>Bioprocess Solutions    |過濾 | 純化應用<br/>Filtration | Purification   |收獲/收槽<br/>Harvesting

Sartoclear Dynamics®


Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology.




Single-use Clarification Systems for up to 2,000 Liters

Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology.

Inspired by the plasma industry, Sartoclear Dynamics® is based on the principles of body feed filtration. The ready-to-use clarification system enables single-use processing up to 2,000 liters. As a result, it replaces centrifuges and the subsequent depth filters in a single step.

 

Depth Filters and Centrifuges vs. Sartoclear Dynamics®

In the past decade, the productivity of fed-batch mammalian cell cultures has risen significantly. Driven by optimized strains and culture media, biomass concentrations have increased from 1 – 3 g/l to 7 – 10 g/L.

Sartocheck® 4 Plus Filter Tester

Depth Filters and Centrifuges

High biomass concentrations challenge depth filters so that capacities have become very limited. Above 500 L a centrifuge seemed to be inevitable in order to reduce costs and waste.

With 2,000 L single-use bioreactors available a breakthrough technology was needed to enable a fully single-use process.

Sartocheck® 4 Plus Filter Tester

Our Clarification Solution up to 2,000 Liters

Sartoclear Dynamics® is a complete ready-to-use technology designed to harvest your bioreactor. Based on the principles of body feed filtration, it is ideal for high cell density cultures of up to 2,000 liters.

Our solution: The addition of a highly porous filter-aid to the feed stream. This increases the permeability of the filter cake and prevents the filter from getting blocked.

 

Your Benefits

Single-use

Save on an upfront investment in a centrifuge and its high maintenance costs. The single-use process of Sartoclear Dynamics® is fast, clean, reliable, economical and flexible.

Scalability

Do not worry about changing the volume of your bioreactor. You can adapt the amount of DE and the number of Sartoclear Dynamics®filtration units to whatever volume and size you may need. 
With Sartoclear Dynamics® Scale you can easily determine the optimal ratio of DE to your biomass and linearly scale this to your process application.

Speed

The installation is quick and easy and preparation short since you do not have to preflush the filters. Sartoclear Dynamics®works with high flow rates and saves you the secondary step of depth filtration.

Consistency

Thanks to a constant ratio of diatomaceous earth (DE) to your biomass, the performance of Sartoclear Dynamics® is predictable. Variable parameters such as cell viability and cell size do not impact your results.

 

Sartoclear Dynamics® Scale

Our pressure vessels are manufactured in facilities certified for compliance with the European Pressure Equipment Directive 97/23/EC. Flexibility, thorough cleanability and ease of use are the major features of our pressure vessels. Sartorius Stedim Biotech pressure vessels are designed to fulfill our customers’ quality standards and thus completely meet market expectations. We can offer you a standard Tri-clamp connection as body closure but also an aseptic O-Ring connection similar to DIN 11864-3.

Download Data Sheet (254 KB)

Pressure Vessels

 

Safe and Clean Powder Transfer

With Sartoclear Dynamics®, the DE is directly mixed into the cell culture fluid. The innovative powder transfer system ensures a fast and dust-free transfer of the DE.

The powder transfer adapter is mounted on the seal.

 

The Sartoclear Dynamics® DE Powder Bag and the adapter are connected with a functional zipper.

 

Clamps keep the plastic film in position and protect the rails during powder transfer.

 

Reality Check

A large variety of different cell cultures were tested to find the best harvesting conditions for Sartoclear Dynamics® filters. The optimal conditions appeared to be constant for most cell lines.

Publications & Downloads

You can find additional information on Sartoclear Dynamics® products like published articles and manuals in our download section.

 
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Sartoclear Dynamics®

Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology.