BIOSTAT STR® and Flexsafe STR®
Single-Use Production Platform of the Future
Run automated, intensified, predictive processes with BIOSTAT STR®. Ranging from 12.5 L to 2000 L, each bioreactor has a fully scalable, stirred-tank design and offers high performance across a range of processes including high-cell density, microcarrier and perfusion. Flexsafe STR® bags ensure excellent cell growth and robustness combined with single-use, non-invasive sensors for pH, DO, viable biomass monitoring and online glucose and lactate measurement.
The BIOSTAT STR® can be connected to different cell retention devices, to retain viable cells in culture for increased space-time yields or to remove sensitive proteins for immediate purification.
The best-in-class O2 transfer, achieved through our innovative sparging solutions and excellent mixing, reduces foaming and hence the risk for pressure built-up. High-cell densities can be achieved and maintained over extended periods of time.
Ease of Use
The unique ease-of use concept of the BIOSTAT STR® covers all aspects of bioreactor operation including bioreactor control:
- Intuitive and comfortable screen interface
- Plug and play integration into third party SCADA (e.g. DeltaVTM)
- Large doors and installation robot for fast and straightforward installation of the bag
- Large sensor windows for easy access to lateral ports and sensors
Cell Growth and Robustness
Flexsafe® bags are a member of the bioprocessing bag family with optimized resin formulation and minimized additive package. The complete control of the raw materials, the extrusion process and the bag assembly guarantees consistent lot-to-lot cell growth performance. The thickness, strength and flexibility of the polyethylene film enhances the mechanical robustness of Flexsafe® - making it ideal for all bioprocessing applications.
Save engineering runs, simplify your scale up and scale down, reduce risks in your process transfers. Easily switch between reusable and single-use bioreactors. Experience true scalability in single-use from ambr® 250 to BIOSTAT STR® 2000. The scale conversion software automates translation of scale dependent parameters. In combination with our worldwide pool of application specialists and experts it guides you effectively through the entire scaling process.
Configure Your BIOSTAT STR® to Your Specific Needs
The systems and bags are individually configurable, offering multiple options to cover all process demands.
BIOSTAT STR® platform flexibility with modular bag and instrument designs fit the demands of different process needs. Our application specialist assist you with the standard operation procedure (SOP) conversion from your existing technology.
Choose between different advanced sensor options for viable biomass measurement (BioPAT® ViaMass), off-gas analysis (BioPAT® Xgas) or online monitoring of glucose and lactate (BioPAT® Trace). Easily connect your BIOSTAT STR® to our BioPAT® MFCS or third party supervisory controller. Straightforward integration into existing automation infrastructure provides you with data consistency across scales and throughout the entire process.
Benefit from Advanced Additive Flow. Route air, O2, N2 and CO2 to the sparger and/or to the overlay. Select mass flow controllers for each flow path and switch gases between overlay and sparger.