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BIOSTAT® RM


The BIOSTAT® RM, a fully GMP compliant, single-use, wave-mixed bioreactor and single use Flexsafe® bags are proven for a broad range of different cell lines incl. CHO, NS0, SF9, E.coli and mesenchymal stem cells.




BIOSTAT® RM and Flexsafe® RM for Seed and Small Scale Protein Supply

The BIOSTAT® RM, a fully GMP compliant, single-use, wave-mixed bioreactor and single use Flexsafe® bags are proven for a broad range of different cell lines incl. CHO, NS0, SF9, E.coli and mesenchymal stem cells.

 

Volumes:

  • 100 ml to 100 L
  • Two Rocker sizes: BIOSTAT® RM 20/50 and BIOSTAT® RM 200

Why choose BIOSTA® RM?

  • Excellent Cell Growth and Robustness
  • Security of Supply & Consistent Quality
  • Easy to Use Rocker with Advanced Control Capabilities
 

Cells

  • Mammalian, insect and plant cell
  • Suspension or adherent cells on micro-carriers
  • Shear sensitive cells such as stem cells
  • Low to medium density microbial cultures

Process Step

  • Seed expansion for large bioreactors
  • GMP Production

Purpose

  • Process transfer from shake or T-flask
  • Rapid material supply for pre-clinical trials
  • Production of recombinant proteins, mAbs and vaccines
  • Continuous cultures with reported cell densities of 150 million cells/ml

BIOSTAT® RM 20/50 basic


stand-alone unit for benchtop use

It is a perfectly sized, stand-alone bioreactor for benchtop use. An exchangeable bag holder fits bags from 1 L to 50 L total volume.

Basic rocker with integrated local controller, Air | CO2 mixing module and load cells is the optimal choice for straight forward applications such as seed generation.

  • Space-saving, individual control of two bags on the same platform
  • Advanced alarming and safety features for safe cultivation
  • Reduced manual handling by automated sampling function
 

Advanced Control System


BIOSTAT® B Control Tower with BIOSTAT® RM 20/50 and Flexsafe® RM bag

Do you want to run fully automated and controlled batch, fed-batch or high cell density perfusion cultures? Combine your BIOSTAT® RM basic rocker with our BIOSTAT® B control tower and use Flexsafe® RM bags equipped with single-use pH, DO and now also viable biomass probes.

  • Advanced control of gas mixture and volume, filling volume and substrate addition
  • Extra small space requirement with TWIN configuration – two culture systems  controlled by one controller at the same time
  • The BIOSTAT® B controller is designed to work with a conventional glass vessel, the single-use UniVessel® SU and the BIOSTAT® RM rocker
 

New BioPAT® ViaMass* – single-use biomass sensor

Suitable for non-invasive measurement of viable biomass. Biostat® RM is the only rocking motion bioreactor with inline single-use biomass monitoring.

  • Reduce your contamination risk by using inline single use cell growth monitoring, e.g. in cell therapy or other critical applications.

*Manufactured under the Licence of Hamilton.

 

BIOSTAT® RM 200

The Biostat® RM 200 system consists of the Biostat® RM 200 rocker, Biostat® B control tower on a lab-cart and Flexsafe® RM 100L or 200L cultivation bag. It is your choice for larger scale seed expansion and production of material for preclinical and clinical studies.

It supports working volumes from 10 L up to 100 L.

  • Same well known BIOSTAT® B control tower enables flexible process strategies
  • Low consumable costs compared to stirred single-use bioreactors
  • Designed for automated batch, fed-batch and perfusion processes
  • Reliable single-use probes for measurement of pH and DO
  • Flexible arrangement of control tower and rocker unit on individual trolleys

Flexsafe® RM - a member of Flexsafe® Bag Family

Flexsafe® RM is a single-use bioreactor bag and a member of our bioprocessing bag family with outstanding film quality. Benefit from the same polyethylene film material across all your cell culture steps.
Use our Flexsafe® RM bags in your seed train and scale-up to our BIOSTAT® STR single-use stirred tank bioreactors equipped with Flexsafe® STR bags.

Flexsafe® RM bags fit on rocking motion bioreactors from several manufacturers.

  • Excellent and Reproducible Cell Growth
  • Security of Supply and Consistent Quality
  • Robustness  - Superior Strength and Flexibility of Film

SCADA Software for Bioprocess Management

Additionally to BioPAT® MFCS/DA, the feature-rich BioPAT® MFCS/win supports the most demanding research and production environment with advanced documentation and reporting functionalities. BioPAT® MFCS/win includes ANSI/ISA 88.01 and 21 CFR Part 11 compliance. Multi-user network access to up to 16 process units and remote alarming represent only two additional features.

  • For upstream and downstream unit operations
  • From shake flasks to large-scale bioreactors
  • For single-use and reusable applications

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BIOSTAT® RM

The BIOSTAT® RM, a fully GMP compliant, single-use, wave-mixed bioreactor and single use Flexsafe® bags are proven for a broad range of different cell lines incl. CHO, NS0, SF9, E.coli and mesenchymal stem cells.