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BIOSTAT Cplus


In-Situ Sterilisable Bioreactors. Compact Solution for Research and small-scale production from 2 to 30 l.




BIOSTAT Cplus


The Stainless Steel Fermenter | Bioreactor for Your Laboratory


The BIOSTAT® Cplus is a Sterilizable-In-Place (SIP) Fermenter | Bioreactor developed for the cultivation of microorganisms and cell cultures. Culture vessels with operating volumes of 5 l, 10 l, 15 l, 20 l and 30 l are available. With more than a thousand installations worldwide, the BIOSTAT® Cplus is the most successful stainless steel bioreactor of its class and is now available in the revised 3rd generation with DCU controller.


Features & Benefits:

  • Cost-effective integration into existing infrastructure, choice between electro or steam heating for operation and sterilization
  • Powerful DCU automation platform with newly added functions, e.g. “advanced DO controller,” gravimetric feed control and up to four mass flow controllers
  • Compact, mobile design saves valuable laboratory spaceli>
  • Safe to use due to maintenance-free agitator motor and automatic sequences for sterilization and pressure hold test



The modular design allows for individual system configuration in order to meet your application-specific requirements, from the basic configuration through to sophisticated equipment with e.g. resterilizable addition valve, automatic pressure control, containment sampling, integrated off-gas measurement, and much more.

Applications

  • Process development for: vaccine, recombinant protein and monoclonal antibody production, biofuels and the production of secondary metabolites
  • Process strategy development in batch, fed-batch, continuous or perfusion operation
  • Scale-up and scale-down experiments
  • High cell density fermentation
  • Suspension cultures and adherent cell culture with micro carriers
  • Cultivation of filamentous organisms

In designing the new BIOSTAT® Cplus, we focused on ease of use, simple cleaning and a space-saving design.

Motor Holder
The motor holder is screwed to the frame. This helps you to position the motor easily and securely if the culture vessel needs to be opened.

Lid lifting Device
The lid lifting device enables the easy removal of the lid and allows for simple and safe handling during cleaning work or when changing culture vessel accessories.

Casters
The casters mean that the system is completely mobile. You can move it to another laboratory or simply out of the way when cleaning the floor.

Controller

Controller The DCU controller is one of the best, most secure and flexible control solutions both in upstream and in the downstream processes, and is now an integral part of the new BIOSTAT® Cplus. In addition to the measurement and control tasks as well as the process control for the sterilization of the culture vessel, it is now possible to integrate up to four mass flow controllers and up to two scales or gravimetric feed controllers. In addition, a pressure hold test sequence for the culture vessel and the "advanced DO controller" are optionally available.

Advanced DO Controller

In comparison with the conventional DO control cascade, the "advanced DO controller" supports the sequential and parallel operation of up to 5 slave controllers. The controller can be easily configured using the touch screen and results are graphically displayed as a polygonal curve, which is easy to understand. As a result, you benefit from maximum flexibility for optimal oxygen regulation in your process.


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BIOSTAT Cplus

In-Situ Sterilisable Bioreactors. Compact Solution for Research and small-scale production from 2 to 30 l.