Serum-free media formulations must satisfy a number of nutritional and physical requirements of cells that are normally addressed by the presence of serum. Serum proteins, such as albumin, fibronectin, and fetuin serve a variety of functions that include adsorbing toxic compounds, providing protection against shear forces in bioreactors, creating a matrix for cellular attachment to surfaces, and acting as a carrier for lipids and other growth factors.
Sartorius offers an extensive array of downstream processing buffers and reagents for protein, cellular, and viral-based therapeutic.
Microbiology products for microbial enumeration, air monitoring and sterility testing: membranes, single use devices and instruments for microbial enumeration by the membrane filtration method, instruments and disposable plates for sampling of airborne microorganisms as well as disposable closed systems for the compendial sterility testing and PCR-based tests for Mycoplasma contamination control represent a broad range of advanced microbiology products.
Advanced chemometric methods as Design of Experiments (DoE) and Multivariate Data Analysis (MVDA) enable to look into cost savings besides ensuring process reliability and robustness. DoE is a standard technique to accelerate process development tasks and gain additional process understanding with a least amount of experiments. MVDA techniques are used for scale- and batch-to-batch comparison investigations, and are making inroads into continuous real-time quality control and assurance.