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Your Complete Bioreactor Platform from Cell Line Development to Commercial Manufacturing
Simplify Your Scale-up and Scale-down, Minimize the Risk of Process Transfers and Get the Best Solution for High Cell Density and Continuous Cultures
The Sartorius range of bioreactor platforms have been developed with similar standard geometries to maximise performance and simplify transition between scales. The dedicated MFCS SCADA software ensures easy and reliable data management and control across all platforms. Integrated chemometrics simplify the application of design of experiments (DoE) and multivariate data analysis (MVDA) and enable implementation of Quality by Design (QbD) principles.
Sartorius offers classic stirred-tank design in single-use bioreactors, from ambr® 15 to BIOSTAT STR® 2000.
Make the Right Choices from the Start
ambr® 15 has been proven by industry leaders to provide better scalability than a shake flask. It has transformed cell line development in many leading biopharma companies worldwide by enabling the selection and development of cell lines under true bioreactor conditions. This ensures that only the most productive cell lines are taken forward into development with the confidence that they will perform just as well at production scale.
Accelerate and Simplify Process Development
High Throughput Process Development Tools Enabling Effective QbD Strategies
ambr® 250 automated multi-parallel mini bioreactors enhanced with modern chemometrics tools enable fast and reliable development and optimization of your process. Seamless transfer to our pilot and production scale single-use bioreactor BIOSTAT STR® is ensured through our understanding of bioreactor design and scale-up principles.
High-Throughput Bioprocess Development
Kistler, Pollard, Lee, Streefland (2016) Genetic Engineering & Biotechnology News (Vol. 36, No. 7) Apr 2016
Bioprocess engineers are achieving better process understanding and more optimal cell culture conditions by using high-throughput scale-down methods and design of experiment (DOE) approaches.
This bioprocessing tutorial explains how process development scientists can use the ambr® 250 automated bioreactor system to screen a wide process design space, while minimizing resources and materials.
Get to the Clinic Faster with Single-Use Production Solutions
The seamless scalability of our bioreactor portfolio is further enhanced with scaling tools to ensure straightforward scale up of processes and minimize the time to get material for clinical trials. The BIOSTAT STR® family is the ideal platform for your single-use production needs. Our holistic process safety concept based on our Flexsafe® bags, easy installation and pre-use bag testing makes single-use bioreactor operation reliable, safe and easy.
Looking for a stainless steel option, we have a proven solution with our BIOSTAT® D-DCU and our large scale engineering platform.
Better Scale-Down Models
Advanced Process Optimization and Characterization That Provides Enhanced Emulation of Large Scale Production Systems
Our benchtop fermenters | bioreactors are designed to meet the broad requirements of process optimization and characterization in the biotech and biopharmaceutical industry. The new BIOSTAT® B-DCU provides enhanced functionality, an unrivalled level of process control options for cell culture and microbial processes and full connectivity to third party supervisory software, making it the ideal scale-down model for your large scale process.
Single-Use Manufacturing Has Never Been Easier
Robust and Easy-To-Use Production Platform
The BIOSTAT STR® single-use bioreactor family is the ideal platform for your flexible manufacturing facility. Our proven and scalable stirred tank design enables fast capacity creation and process transfers within your commercial manufacturing network. Forget about cell growth issues, Flexsafe® STR bags ensure consistent lot-to-lot growth performance due to control of the resin and additive package, film extrusion and bag manufacturing.