BioPAT® ViaMass is a system for measuring viable biomass in cell culture processes. Unlike known reference methods, this system is completely integrated into single-use bioreactors. It determines the biomass directly in line, reducing the need for manual sampling. Integrated into the bioreactor’s DCU control system, BioPAT® ViaMass permits automatic monitoring and control of viable biomass.
Process Analytical Technology (PAT) is much more than just one sensor integrated i...
Process Analytical Technology is much more than just one sensor integrated into a process. Process Analytical Technology is a risk-based strategy for designing, analyzing and controlling manufacturing processes. The Critical Process Parameters (CPPs) are identified in line with the definition of the Critical Quality Attributes (CQAs) of intermediates or final products. Process Analytical Technology offers a number of tools for measuring and controlling these CPPs. Sartorius has the right choice of solutions you need: discover our world of Synchronized Process Analytical Technology Solutions.
BioPAT® Trace is an analysis system for simultaneous online monitoring of glucose and lactate in laboratory and industrial cultivations of microorganisms and cell lines. BioPAT® Trace ensures a high degree of measurement performance and process reliability due to its unique combination of a reusable analyser and single-use enzymatic sensors and fluidic elements.
BioPAT® Spectro NIR process sensor monitors the fermentation process inline by providing real-time feedback. Monitoring the process values during biotechnological fermentation is crucial for maintaining the high efficiency and quality of a bioprocess. Although commercial sensor systems are available for real-time monitoring of some variables, such as pH or the concentration of dissolved oxygen, BioPAT® Spectro provides monitoring capabilities that are light years beyond such sensor systems.
Near infrared spectrometers (NIR spectrometers) enable simultaneous measurement of chemical compounds and physical properties. Designed for process control, Sartorius NIR process analysers can be used in a wide range of applications, such as monitoring and control of mixing and inline dilution processes, determination of homogeneity and of the end point, as well as recipe management and ingredient optimisation.
Along the bioprocess chain a range of sensors supplementing our broad range of equipment is provided for advanced process monitoring and control. Sartorius single use sensor technologies are combined with hardware and software controllers as well as data acquisition systems for fully integrated solutions. The single use philosophy in bioprocesses demands ready to use, pre-calibrated and pre-sterilized sensors.
The BioPAT® Xgas monitors and controls bioprocesses in real time. It is a combined oxygen-carbon dioxide sensor featuring automatic compensation of humidity and pressure. The range for oxygen is 1 - 50% and for carbon dioxide 0 - 10%, with ±3% accuracy on the reference value and a difference of less than ±0.2% on the reading. The sensor is non-invasive and can be conveniently integrated onto a new Sartorius Stedim bioreactor exhaust line or your current system.
The probe operates on a transmittance principle using IR light to track total biomass. It is a tool to increase microbial fermentation yield by maximizing the use of nutrients, gases and other critical parameters. The system reduces the cost associated with 24-hour sampling and removes inconsistent off-line analysis. The BioPAT® Fundalux comes integrated into our BioPAT® DCU and automatic data conversion to optical density can be achieved with BioPAT® MFCS.